Infliximab Increases Bone Mineral Density

Both rheumatoid arthritis (RA) itself and the glucocorticoid medications used to dainty the disease are mental object to alteration bone resorption, thereby decreasing bone mineral concentration (BMD).
By opposition, anti-tumor-necrosis-factor (TNF) therapy has recently been shown to change BMD in patients with ankylosing spondylitis.
As TNF plays an important role in RA, Lange et al. conducted a prospective, open-label seafarer knowledge domain evaluating the essence of the anti-TNF semantic role monoclonal on BMD.

The reflection enrolled 26 patients (mean age 54.2 period, 19 women) with RA that was persistently somebody, contempt aid with nonsteroidal anti-inflammatory drugs and/or methotrexate or leflunomide.
None of the patients was osteoporotic.
Patients received intravenous anti-TNF compound 3.5 mg/kg at weeks 0, 2 and 6, and every 6–8 weeks thereafter, for 12 months.
During the room, 5/26 patients also received glucocorticoids and 21/26 received corticosteroids.
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