Infliximab in combination with leflunomide. Part 2

The main reasons for drug birth control were adverse
events (23.5%) and inefficacy (4%); and one participant role was
temporarily taken off aggregation therapy before operation.

Adverse events were reported in a totality of 75 patients (33.3%).
Of these, 35% were on monoclonal and leflunomide and 27.8% were on mathematical process therapy with azathioprine.
The researchers info that no unexpected side effects were observed.

Infections (6.2%).Cytopenia (5.8%).Hepatotoxicity (5.8%).Instilment reactions (5.3%).Skin reactions (4%).

“In
our rumination, no case of cutaneous vasculitis was observed,” the
researchers write. “We also found that adverse events tended to be more
frequent when leflunomide was introduced concomitantly with or after
monoclonal.” They note that these results are consistent with a written
report that adverse events from leflunomide were more frequent at the
outset of direction. “The simultaneous presentation of leflunomide and
anti-TNF compound therapy might contribute to the pretense of mental
attitude reactions.”

Perdriger and colleagues note
that there are no published data on the use of azathioprine in social
unit with monoclonal in patients with rheumatic diseases.
However, they say the status of this change of integrity is well
established in patients with Crohn’s disease, where responses are
longer lasting when monoclonal antibody is used with immunosuppressive
agents.

“Overall,”
they note, “our retrospective field of study on bit use of monoclonal
combined with leflunomide or azathioprine suggests no increment in the
absolute frequency of adverse effects congeneric to the monoclonal
antibody and methotrexate aggregation.”
This is a part of article Infliximab in combination with leflunomide. Part 2 Taken from "Arava Information" Information Blog